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KMID : 0359920110300020141
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Korean Journal of Nephrology
2011 Volume.30 No. 2 p.141 ~ p.147
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One-Year Mortality of Acute Kidney Injury in Patients with Acute Myocardial Infarction
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Lim Dae-Hun
Jeong Jong-Hyeok
Jeong Ji-Min
Kim Chang-Seong
Choi Joon-Seok
Park Joung-Woo
Bae Eun-Hui
Ma Seong-Kwon
Kim Soo-Wan
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Abstract
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Purpose:Acute kidney injury (AKI) is a common complication during hospitalization and is an accepted risk factor for in-hospital mortality. However, the association of severity of AKI with the long-term risk of death is not well known. This study aimed to investigate the incidence and clinical significance of AKI in patients with acute myocardial infarction (AMI).
Methods:To examine the effect of the severity of AKI on 1-year risk of death following AMI, we performed an observational study of 1,224 patients admitted for AMI. We evaluated the association between AKI and all-cause mortality. Patients with maintaining hemodialysis treatment (n=7), and who died during hospitalization (n=71) were excluded. Remaining 1146 patients were divided into three groups according to the Acute Kidney Injury Network (AKIN) criteria (Stage-1, -2, and-3). The primary end point of the study was 1-year all-cause mortality after hospital discharge. The relation between the severity of AKI and 1-year mortality after AMI was analyzed.
Results:AKI was developed in 222/1,146 (19.3%) patients during the hospital stay. Adjusted hazard ratio for 1-year mortality was 3.064 (95% CI 1.618 to 5.803, p=0.001), 6.112 (95% CI 2.344 to 15.935, p<0.001) and 20.030 (95% CI 5.428 to 73.912, p<0.001) in stage-1, -2, and stage-3 AKI groups
compared with that of no AKI group.
Conclusion:The severity of AKI is strongly related to 1-year all cause mortality in patients with AMI.
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KEYWORD
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Acute kidney failure, Myocardial infarction, Fatal outcome
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